Written Protocol · PharmD

Puerto Rico “Protocol” for Pharmacists

Required. The “Protocol” is the written instrument Puerto Rico law names for a Pharmacist working with a physician. Below: the board that governs it, what it must contain, and the terms it has to carry.

Practice authoritySupervision required
Written agreementAgreement required
What Puerto Rico calls it“Protocol”
Governing boardPuerto Rico Board of Pharmacy
Agreement familyCollaborative Practice
Research date2026-09-03 · clauses 2026-09-03

Represents Ley 247-2004's collaborative 'Protocolo' tier ('cuidado farmacéutico' under a written physician-pharmacist agreement) and its separate vaccine-administration certificate, not ordinary dispensing licensure, which is out of scope here. No board-certification/residency requirement or per-physician cap was found, unlike NC's CPP.

What a Puerto Rico “Protocol” must contain

Governed by the Puerto Rico Board of Pharmacy. Each numbered item is a statutory requirement the agreement must satisfy.

  1. The Pharmacist may manage the patient's pharmacotherapy on a collaborative basis with the Physician only under a written "Protocol" between the Physician (or a group of physicians) and the Pharmacist, prepared consistent with guidelines the Puerto Rico Board of Pharmacy establishes under the Ley de Farmacia de Puerto Rico. Puerto Rico law does not permit the Pharmacist to practice under such a Protocol in its absence.

    Source: Ley Núm. 247 de 3 de septiembre de 2004, según enmendada ("Ley de Farmacia de Puerto Rico")

  2. The “Protocol” on file also carries 1 registration, 1 authority clauses, generated in the document itself.

Statutes and rules cited

  1. Ley Núm. 247 de 3 de septiembre de 2004, según enmendada ("Ley de Farmacia de Puerto Rico")statute

    Puerto Rico Pharmacy Act, published by the Puerto Rico Department of Health, providing for a Board-defined "Protocol" under which a pharmacist and a physician (or group of physicians) may agree that the pharmacist will manage a patient's pharmacotherapy on a collaborative basis.

Terms it has to carry

Ratio, proximity, chart review, meeting and prescribing terms the agreement has to carry, from the state's supervision rules.

Proximity

Not codified — left to the agreement

Supervision ratio

Not codified — no cap on file

Chart review

Not codified — left to the agreement

Meeting cadence

vaccine-administration certificate renewal: Annually

Certified pharmacists must complete ≥1 contact hour/year of immunization CE and maintain current CPR certification to keep the 3-year vaccine-administration certificate active; not a physician-meeting requirement as such.

Prescriptive authority

Covered by the practice agreement · no controlled-substance authority

Ley 247-2004 defines a 'Protocolo' allowing a pharmacist to initiate or modify a patient's pharmacotherapy collaboratively with a physician or group of physicians, and separately lets certified pharmacists administer influenza/pneumococcal/Td-Tdap vaccines to patients ≥12 without a medical order. No provision authorizing controlled-substance prescribing under a Protocolo was found — set to False rather than assumed; verify with the Junta de Farmacia before relying on this.

Written agreement

Required

Practice ownership (corporate practice of medicine)

Non-licensee ownership permitted — No pharmacist-ownership requirement for a 'farmacia' was confirmed in this research pass — large non-pharmacist-owned chain pharmacies operate openly in PR, suggesting a permissive regime similar to NC/VA, but the specific Ley 247-2004 ownership provision was not located and reviewed directly — treat as probable, not confirmed.

A licensed 'farmacéutico regente' (pharmacist of record) must be named and is responsible for compliance regardless of who owns the pharmacy.

Legal sources for these rules (2)
How the relationship works day to day
Who has to be where, how often you meet, and what the physician costs: Pharmacist in Puerto Rico on collaborativeagreement.com.

About Puerto Rico's rules

PR's 'Médico Asistente' (PA) credential is NOT the mainland PA profession — it is a bridge pathway mainly for internationally-trained physicians awaiting PR licensure (Ley 71-2017), capped at 2 per supervising physician with zero prescriptive authority. APRNs (NP/CNM/CRNA/CNS) need patient-level collaborative protocols with a physician for nearly all diagnostic/prescriptive functions (Ley 254-2015) despite AANP rating PR 'Reduced Practice.' No dedicated esthetician license currently exists.

Other clinicians in Puerto Rico: see the state overview.